BRD-K21680192_mitoxantrone_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APOE apolipoprotein E
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BCL2A1 BCL2-related protein A1
BGN biglycan
CADM1 cell adhesion molecule 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLEC7A C-type lectin domain family 7, member A
COL1A1 collagen, type I, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DAZAP2 DAZ associated protein 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EHD3 EH-domain containing 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IL1B interleukin 1, beta
IL6 interleukin 6
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
LPXN leupaxin
LXN latexin
MAMLD1 mastermind-like domain containing 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
MTSS1 metastasis suppressor 1
NPR3 natriuretic peptide receptor 3
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
RGS4 regulator of G-protein signaling 4
RPL37A ribosomal protein L37a
RPL39L ribosomal protein L39-like
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SULF1 sulfatase 1
TBXA2R thromboxane A2 receptor
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TMOD1 tropomodulin 1
TP53 tumor protein p53
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
ANXA1 annexin A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
CALML3 calmodulin-like 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD24 CD24 molecule
CDA cytidine deaminase
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPF centromere protein F, 350/400kDa
CHD9 chromodomain helicase DNA binding protein 9
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CLCA2 chloride channel accessory 2
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL1A2 collagen, type I, alpha 2
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GUSBP11 glucuronidase, beta pseudogene 11
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA10 homeobox A10
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
IVNS1ABP influenza virus NS1A binding protein
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KRT15 keratin 15, type I
KRT23 keratin 23, type I
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYRF myelin regulatory factor
NELL2 NEL-like 2 (chicken)
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
OSBPL10 oxysterol binding protein-like 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RTN1 reticulon 1
SASH1 SAM and SH3 domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT3 sirtuin 3
SLC35E2B solute carrier family 35, member E2B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNJ2 synaptojanin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
ZFP36L1 ZFP36 ring finger protein-like 1