BRD-K21680192_mitoxantrone_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

402 genes differentially expressed following the BRD-K21680192_mitoxantrone_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
AMACR alpha-methylacyl-CoA racemase
ANKRD36B ankyrin repeat domain 36B
AREG amphiregulin
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BASP1 brain abundant, membrane attached signal protein 1
BDKRB2 bradykinin receptor B2
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C8ORF4 chromosome 8 open reading frame 4
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN1 claudin 1
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CRIP1 cysteine-rich protein 1 (intestinal)
CTSB cathepsin B
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
EPHA3 EPH receptor A3
EPS8L2 EPS8-like 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAM134A family with sequence similarity 134, member A
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
INSIG2 insulin induced gene 2
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
ISCU iron-sulfur cluster assembly enzyme
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LEPROT leptin receptor overlapping transcript
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100272216 uncharacterized LOC100272216
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTBP1 latent transforming growth factor beta binding protein 1
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
NCF2 neutrophil cytosolic factor 2
NMRK1 nicotinamide riboside kinase 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PERP PERP, TP53 apoptosis effector
PHLDA3 pleckstrin homology-like domain, family A, member 3
PI3 peptidase inhibitor 3, skin-derived
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLD3 phospholipase D family, member 3
PLEK pleckstrin
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
PTGES prostaglandin E synthase
PTN pleiotrophin
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC1 serine incorporator 1
SESN1 sestrin 1
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TIGAR TP53 induced glycolysis regulatory phosphatase
TM2D1 TM2 domain containing 1
TMEM45A transmembrane protein 45A
TMEM59 transmembrane protein 59
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
VNN1 vanin 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CRTAP cartilage associated protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EMX2 empty spiracles homeobox 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FXYD2 FXYD domain containing ion transport regulator 2
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPHN gephyrin
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAMLD1 mastermind-like domain containing 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
ORC6 origin recognition complex, subunit 6
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDLIM3 PDZ and LIM domain 3
PDZRN3 PDZ domain containing ring finger 3
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOBTB3 Rho-related BTB domain containing 3
RNASEH2A ribonuclease H2, subunit A
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein