BRD-K21680192_mitoxantrone_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K21680192_mitoxantrone_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
C4ORF27 chromosome 4 open reading frame 27
CADM1 cell adhesion molecule 1
CECR1 cat eye syndrome chromosome region, candidate 1
CETN3 centrin, EF-hand protein, 3
CLDN10 claudin 10
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLTF helicase-like transcription factor
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MDK midkine (neurite growth-promoting factor 2)
MXRA5 matrix-remodelling associated 5
NID2 nidogen 2 (osteonidogen)
NOTCH3 notch 3
NSG1 neuron specific gene family member 1
PCOLCE procollagen C-endopeptidase enhancer
PDIA4 protein disulfide isomerase family A, member 4
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
SCG2 secretogranin II
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX2 T-box 2
TFPI2 tissue factor pathway inhibitor 2
TMEM30B transmembrane protein 30B
TMEM47 transmembrane protein 47
TMOD1 tropomodulin 1
TPGS2 tubulin polyglutamylase complex subunit 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
ALB albumin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AXL AXL receptor tyrosine kinase
BMP2 bone morphogenetic protein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CCNF cyclin F
CDCA4 cell division cycle associated 4
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IL4R interleukin 4 receptor
JMJD6 jumonji domain containing 6
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MTF2 metal response element binding transcription factor 2
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RPL37A ribosomal protein L37a
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SDC4 syndecan 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SPRY2 sprouty homolog 2 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
UGCG UDP-glucose ceramide glucosyltransferase
VCL vinculin
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36 ZFP36 ring finger protein
ZNF281 zinc finger protein 281