BRD-K21680192_mitoxantrone_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

155 genes differentially expressed following the BRD-K21680192_mitoxantrone_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CADM1 cell adhesion molecule 1
CD4 CD4 molecule
CD84 CD84 molecule
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CSTA cystatin A (stefin A)
CTSB cathepsin B
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CYB561 cytochrome b561
CYBB cytochrome b-245, beta polypeptide
DEFB1 defensin, beta 1
DMXL2 Dmx-like 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
E2F2 E2F transcription factor 2
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FECH ferrochelatase
FMO2 flavin containing monooxygenase 2 (non-functional)
FRY furry homolog (Drosophila)
GC group-specific component (vitamin D binding protein)
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
HRG histidine-rich glycoprotein
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MDFIC MyoD family inhibitor domain containing
MMP1 matrix metallopeptidase 1
MXI1 MAX interactor 1, dimerization protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NGRN neugrin, neurite outgrowth associated
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OVGP1 oviductal glycoprotein 1, 120kDa
PAEP progestagen-associated endometrial protein
PCBP2 poly(rC) binding protein 2
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEX11A peroxisomal biogenesis factor 11 alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRD protein tyrosine phosphatase, receptor type, D
RAB25 RAB25, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
STAP2 signal transducing adaptor family member 2
SULF1 sulfatase 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TCF4 transcription factor 4
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
CA2 carbonic anhydrase II
CCNA2 cyclin A2
COA3 cytochrome c oxidase assembly factor 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GLOD4 glyoxalase domain containing 4
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MRPL12 mitochondrial ribosomal protein L12
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTRF polymerase I and transcript release factor
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STIP1 stress-induced phosphoprotein 1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4