BRD-K21680192_mitoxantrone_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-K21680192_mitoxantrone_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACLY ATP citrate lyase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOC1 apolipoprotein C-I
APOLD1 apolipoprotein L domain containing 1
ASPN asporin
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BHMT2 betaine--homocysteine S-methyltransferase 2
BTG3 BTG family, member 3
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5AR1 complement component 5a receptor 1
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CA11 carbonic anhydrase XI
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL13A1 collagen, type XIII, alpha 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM46A family with sequence similarity 46, member A
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FKBP14 FK506 binding protein 14, 22 kDa
FST follistatin
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GBP1 guanylate binding protein 1, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GTF2B general transcription factor IIB
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL11 interleukin 11
IL6 interleukin 6
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
ODC1 ornithine decarboxylase 1
PAEP progestagen-associated endometrial protein
PDHX pyruvate dehydrogenase complex, component X
PELO pelota homolog (Drosophila)
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PTN pleiotrophin
PTPRG protein tyrosine phosphatase, receptor type, G
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
RPS21 ribosomal protein S21
RRAGD Ras-related GTP binding D
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNAI2 snail family zinc finger 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOD2 superoxide dismutase 2, mitochondrial
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM259 transmembrane protein 259
TMEM45A transmembrane protein 45A
TMOD1 tropomodulin 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXN thioredoxin
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABR active BCR-related
ACD adrenocortical dysplasia homolog (mouse)
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA3 annexin A3
ANXA7 annexin A7
APOD apolipoprotein D
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP9A ATPase, class II, type 9A
BRD7 bromodomain containing 7
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CDCA3 cell division cycle associated 3
CENPF centromere protein F, 350/400kDa
CHMP6 charged multivesicular body protein 6
CLIC4 chloride intracellular channel 4
CLTA clathrin, light chain A
CPNE1 copine I
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
CTSE cathepsin E
CTSH cathepsin H
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP3 dual specificity phosphatase 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FAM171A1 family with sequence similarity 171, member A1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FSTL1 follistatin-like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GLDC glycine dehydrogenase (decarboxylating)
GLOD4 glyoxalase domain containing 4
HN1L hematological and neurological expressed 1-like
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
ITGA6 integrin, alpha 6
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KIAA0368 KIAA0368
KIF1B kinesin family member 1B
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPP LIM domain containing preferred translocation partner in lipoma
LY75 lymphocyte antigen 75
MAPK13 mitogen-activated protein kinase 13
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
MYH10 myosin, heavy chain 10, non-muscle
MYOF myoferlin
NCOA6 nuclear receptor coactivator 6
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOTCH2 notch 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PRKD3 protein kinase D3
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RGS13 regulator of G-protein signaling 13
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCAND1 SCAN domain containing 1
SDC4 syndecan 4
SEPT8 septin 8
SEPW1 selenoprotein W, 1
SETD5 SET domain containing 5
SLC35E2B solute carrier family 35, member E2B
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM9SF3 transmembrane 9 superfamily member 3
TMC5 transmembrane channel-like 5
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
VDAC1 voltage-dependent anion channel 1
XPO7 exportin 7
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF185 zinc finger protein 185 (LIM domain)