BRD-K21680192_mitoxantrone_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

313 genes differentially expressed following the BRD-K21680192_mitoxantrone_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
AOX1 aldehyde oxidase 1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
C1ORF54 chromosome 1 open reading frame 54
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
C5AR1 complement component 5a receptor 1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CD1E CD1e molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN3 claudin 3
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
CLIC5 chloride intracellular channel 5
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSK cathepsin K
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATAD1 GATA zinc finger domain containing 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGN5 high mobility group nucleosome binding domain 5
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
JAM2 junctional adhesion molecule 2
LAMP3 lysosomal-associated membrane protein 3
LPXN leupaxin
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MDK midkine (neurite growth-promoting factor 2)
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOSPD1 motile sperm domain containing 1
MSLN mesothelin
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
OXCT1 3-oxoacid CoA transferase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PIP prolactin-induced protein
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SEC61G Sec61 gamma subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLPI secretory leukocyte peptidase inhibitor
SPDEF SAM pointed domain containing ETS transcription factor
STC1 stanniocalcin 1
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCF4 transcription factor 4
TEK TEK tyrosine kinase, endothelial
TFRC transferrin receptor
THY1 Thy-1 cell surface antigen
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TPGS2 tubulin polyglutamylase complex subunit 2
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSPAN12 tetraspanin 12
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG6 adhesion G protein-coupled receptor G6
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMD1 adenosylmethionine decarboxylase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B3GNT1
BAG3 BCL2-associated athanogene 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK7 cyclin-dependent kinase 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CHEK2 checkpoint kinase 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAM208B family with sequence similarity 208, member B
FAM222B family with sequence similarity 222, member B
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FZD7 frizzled class receptor 7
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GEMIN4 gem (nuclear organelle) associated protein 4
GPATCH8 G patch domain containing 8
GSPT2 G1 to S phase transition 2
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
KRT18 keratin 18, type I
LBR lamin B receptor
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIA melanoma inhibitory activity
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NOTCH2 notch 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PRKCD protein kinase C, delta
PRNP prion protein
PRPF4B pre-mRNA processing factor 4B
PUM2 pumilio RNA-binding family member 2
RBM15 RNA binding motif protein 15
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SCAND1 SCAN domain containing 1
SETD5 SET domain containing 5
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TNC tenascin C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZMIZ1 zinc finger, MIZ-type containing 1