BRD-K21672174_Ro 28-1675 ?_SW620_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K21672174_Ro 28-1675 ?_SW620_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CLGN calmegin
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP2 GTP binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
INHBE inhibin, beta E
INPP1 inositol polyphosphate-1-phosphatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MYOF myoferlin
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PXDN peroxidasin
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC1 syndecan 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TSPAN1 tetraspanin 1
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CKB creatine kinase, brain
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GAS2L1 growth arrest-specific 2 like 1
GNAS GNAS complex locus
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
MRPL57 mitochondrial ribosomal protein L57
MTDH metadherin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PDZK1 PDZ domain containing 1
PLAGL2 pleiomorphic adenoma gene-like 2
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
REEP1 receptor accessory protein 1
SAC3D1 SAC3 domain containing 1
SACS sacsin molecular chaperone
SC5D sterol-C5-desaturase
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBX2 T-box 2
THAP11 THAP domain containing 11
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRBC1 T cell receptor beta constant 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1