BRD-K21672174_Ro 28-1675 ?_MCF7_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K21672174_Ro 28-1675 ?_MCF7_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP6 bone morphogenetic protein 6
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CFDP1 craniofacial development protein 1
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL14A1 collagen, type XIV, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM63A family with sequence similarity 63, member A
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GAS7 growth arrest-specific 7
GCC2 GRIP and coiled-coil domain containing 2
GRN granulin
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRCC1 lysine-rich coiled-coil 1
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPAP2C phosphatidic acid phosphatase type 2C
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAP1GAP RAP1 GTPase activating protein
S100A6 S100 calcium binding protein A6
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3YL1 SH3 and SYLF domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35F2 solute carrier family 35, member F2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
TARS threonyl-tRNA synthetase
TGIF1 TGFB-induced factor homeobox 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
YARS tyrosyl-tRNA synthetase
ZNF131 zinc finger protein 131
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AR androgen receptor
ATF5 activating transcription factor 5
B3GNT1
BCHE butyrylcholinesterase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C14ORF2 chromosome 14 open reading frame 2
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNE2 cyclin E2
CD52 CD52 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYD dihydropyrimidine dehydrogenase
EFNB2 ephrin-B2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FAM3C family with sequence similarity 3, member C
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HHEX hematopoietically expressed homeobox
HIC2 hypermethylated in cancer 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG1 insulin induced gene 1
IPO7 importin 7
JCHAIN joining chain of multimeric IgA and IgM
KLK3 kallikrein-related peptidase 3
LPAR6 lysophosphatidic acid receptor 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
NT5DC2 5'-nucleotidase domain containing 2
OLFM4 olfactomedin 4
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPRC protein tyrosine phosphatase, receptor type, C
SLBP stem-loop binding protein
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SRGN serglycin
TARDBP TAR DNA binding protein
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta