BRD-K21025364_NVP-TAE226_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K21025364_NVP-TAE226_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM10 ADAM metallopeptidase domain 10
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
BANK1 B-cell scaffold protein with ankyrin repeats 1
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRISP3 cysteine-rich secretory protein 3
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DRAM1 DNA-damage regulated autophagy modulator 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GP2 glycoprotein 2 (zymogen granule membrane)
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
KLF9 Kruppel-like factor 9
LTB lymphotoxin beta (TNF superfamily, member 3)
MEIS2 Meis homeobox 2
MYO6 myosin VI
NBEA neurobeachin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PLK2 polo-like kinase 2
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
SC5D sterol-C5-desaturase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
VDAC1 voltage-dependent anion channel 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CDC20 cell division cycle 20
CEP55 centrosomal protein 55kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL9A3 collagen, type IX, alpha 3
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
GTF2A2 general transcription factor IIA, 2, 12kDa
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LMNB1 lamin B1
LMO4 LIM domain only 4
MALL mal, T-cell differentiation protein-like
NEK2 NIMA-related kinase 2
NID2 nidogen 2 (osteonidogen)
PCDH9 protocadherin 9
PDLIM1 PDZ and LIM domain 1
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PSRC1 proline/serine-rich coiled-coil 1
PWP1 PWP1 homolog (S. cerevisiae)
RRBP1 ribosome binding protein 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
STAT4 signal transducer and activator of transcription 4
TAGLN2 transgelin 2
TCP1 t-complex 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TNC tenascin C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZIC1 Zic family member 1
ZW10 zw10 kinetochore protein