BRD-K21025364_NVP-TAE226_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K21025364_NVP-TAE226_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD28 ankyrin repeat domain 28
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CBS cystathionine-beta-synthase
CCNG1 cyclin G1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CERS6 ceramide synthase 6
CPD carboxypeptidase D
CXCL5 chemokine (C-X-C motif) ligand 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP1 fatty acid binding protein 1, liver
FAM63A family with sequence similarity 63, member A
FOXN3 forkhead box N3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KIAA0485 uncharacterized LOC57235
LOX lysyl oxidase
MAP1B microtubule-associated protein 1B
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLSCR4 phospholipid scramblase 4
PRAME preferentially expressed antigen in melanoma
PTX3 pentraxin 3, long
RBKS ribokinase
RGS10 regulator of G-protein signaling 10
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TF transferrin
TMEM140 transmembrane protein 140
TSPAN6 tetraspanin 6
TWF2 twinfilin actin binding protein 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANXA3 annexin A3
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL4A6 collagen, type IV, alpha 6
CRELD2 cysteine-rich with EGF-like domains 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2AFX H2A histone family, member X
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLK5 kallikrein-related peptidase 5
LMO4 LIM domain only 4
LOXL1 lysyl oxidase-like 1
LUM lumican
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
NR1H2 nuclear receptor subfamily 1, group H, member 2
ODC1 ornithine decarboxylase 1
PNP purine nucleoside phosphorylase
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SIK1 salt-inducible kinase 1
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TAGLN2 transgelin 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein