BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CXADR coxsackie virus and adenovirus receptor
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
FBXL12 F-box and leucine-rich repeat protein 12
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JMJD6 jumonji domain containing 6
KRAS Kirsten rat sarcoma viral oncogene homolog
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
OLFML2A olfactomedin-like 2A
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RND3 Rho family GTPase 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APOD apolipoprotein D
CD24 CD24 molecule
CDC42 cell division cycle 42
DCN decorin
DUSP6 dual specificity phosphatase 6
ELOVL2 ELOVL fatty acid elongase 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
HIST1H2BG histone cluster 1, H2bg
IFITM1 interferon induced transmembrane protein 1
LYZ lysozyme
MGP matrix Gla protein
PDGFC platelet derived growth factor C
PSIP1 PC4 and SFRS1 interacting protein 1
SEPP1 selenoprotein P, plasma, 1
SRPX sushi-repeat containing protein, X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRBC1 T cell receptor beta constant 1
TXNIP thioredoxin interacting protein
VCAN versican
VDAC1 voltage-dependent anion channel 1