BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANPEP alanyl (membrane) aminopeptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CD44 CD44 molecule (Indian blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEPT1 choline/ethanolamine phosphotransferase 1
COCH cochlin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP10 dual specificity phosphatase 10
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
JMJD6 jumonji domain containing 6
MCOLN1 mucolipin 1
METRN meteorin, glial cell differentiation regulator
MFAP3L microfibrillar-associated protein 3-like
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
NUTF2 nuclear transport factor 2
PDLIM5 PDZ and LIM domain 5
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SAP30 Sin3A-associated protein, 30kDa
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TXNRD1 thioredoxin reductase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANOS1 anosmin 1
ANXA4 annexin A4
AUTS2 autism susceptibility candidate 2
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FST follistatin
GPC3 glypican 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LRRC17 leucine rich repeat containing 17
MSLN mesothelin
MX2 MX dynamin-like GTPase 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEB nebulin
NR4A1 nuclear receptor subfamily 4, group A, member 1
PEG10 paternally expressed 10
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCI protein kinase C, iota
PTN pleiotrophin
SCGB1D2 secretoglobin, family 1D, member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
THY1 Thy-1 cell surface antigen
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)