BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMDHD2 amidohydrolase domain containing 2
AQP9 aquaporin 9
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C5AR1 complement component 5a receptor 1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CSRP2 cysteine and glycine-rich protein 2
CYBB cytochrome b-245, beta polypeptide
DENND1B DENN/MADD domain containing 1B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP11 FK506 binding protein 11, 19 kDa
GCLC glutamate-cysteine ligase, catalytic subunit
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
IQGAP2 IQ motif containing GTPase activating protein 2
KIF14 kinesin family member 14
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSX1 msh homeobox 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLBD1 phospholipase B domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
TRIB2 tribbles pseudokinase 2
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
FNBP1 formin binding protein 1
ISG15 ISG15 ubiquitin-like modifier
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
NET1 neuroepithelial cell transforming 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RPL37A ribosomal protein L37a
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TSPYL5 TSPY-like 5
UFM1 ubiquitin-fold modifier 1