BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-K20914082_1,2-dimethyl (3R)-4-oxo-3-(propan-2-yl)-3-(thiophen-3-yl)-1,2-diazetidine-1,2-dicarboxylate_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CA2 carbonic anhydrase II
CD163 CD163 molecule
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MT1M metallothionein 1M
NPTX1 neuronal pentraxin I
NQO1 NAD(P)H dehydrogenase, quinone 1
NVL nuclear VCP-like
PERP PERP, TP53 apoptosis effector
RPS4Y1 ribosomal protein S4, Y-linked 1
SH3YL1 SH3 and SYLF domain containing 1
SYBU syntabulin (syntaxin-interacting)
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
AKT3 v-akt murine thymoma viral oncogene homolog 3
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNN3 calponin 3, acidic
FMO2 flavin containing monooxygenase 2 (non-functional)
GPRC5A G protein-coupled receptor, class C, group 5, member A
INHBA inhibin, beta A
KRT7 keratin 7, type II
LCN2 lipocalin 2
LMCD1 LIM and cysteine-rich domains 1
MDFIC MyoD family inhibitor domain containing
MEOX2 mesenchyme homeobox 2
MLPH melanophilin
NID2 nidogen 2 (osteonidogen)
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TM4SF1 transmembrane 4 L six family member 1