BRD-K20755323_-666_VCAP_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K20755323_-666_VCAP_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAP2 ArfGAP with dual PH domains 2
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CRLF1 cytokine receptor-like factor 1
CTH cystathionine gamma-lyase
CTSE cathepsin E
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EPCAM epithelial cell adhesion molecule
EPRS glutamyl-prolyl-tRNA synthetase
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GUSBP11 glucuronidase, beta pseudogene 11
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LARP6 La ribonucleoprotein domain family, member 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAT1 phosphoserine aminotransferase 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RPL10 ribosomal protein L10
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBL1X transducin (beta)-like 1X-linked
TES testin LIM domain protein
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF116 chromosome 1 open reading frame 116
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAST calpastatin
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD81 CD81 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FNBP1 formin binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GPX1 glutathione peroxidase 1
GTSE1 G-2 and S-phase expressed 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KNG1 kininogen 1
KRT4 keratin 4, type II
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCM4 minichromosome maintenance complex component 4
MME membrane metallo-endopeptidase
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
PCNA proliferating cell nuclear antigen
PLAU plasminogen activator, urokinase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1 pituitary tumor-transforming 1
RAB4A RAB4A, member RAS oncogene family
S100A9 S100 calcium binding protein A9
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPRR1B small proline-rich protein 1B
TACC3 transforming, acidic coiled-coil containing protein 3
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)