BRD-K20755323_-666_NCIH596_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K20755323_-666_NCIH596_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARMCX2 armadillo repeat containing, X-linked 2
ATM ATM serine/threonine kinase
BLNK B-cell linker
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAST calpastatin
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC11A C-type lectin domain family 11, member A
COL5A1 collagen, type V, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
DENND2D DENN/MADD domain containing 2D
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM69A family with sequence similarity 69, member A
FBP1 fructose-1,6-bisphosphatase 1
FBXL7 F-box and leucine-rich repeat protein 7
FCGBP Fc fragment of IgG binding protein
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
GAGE3 G antigen 3
GSDMB gasdermin B
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INHBB inhibin, beta B
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
LYPD3 LY6/PLAUR domain containing 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MXRA5 matrix-remodelling associated 5
MZB1 marginal zone B and B1 cell-specific protein
NELL2 NEL-like 2 (chicken)
NR2F6 nuclear receptor subfamily 2, group F, member 6
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PERP PERP, TP53 apoptosis effector
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
POU2AF1 POU class 2 associating factor 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RAI14 retinoic acid induced 14
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RTN1 reticulon 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SESN1 sestrin 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TDO2 tryptophan 2,3-dioxygenase
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TMEM176B transmembrane protein 176B
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMACR alpha-methylacyl-CoA racemase
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRDL1 chordin-like 1
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
EDNRB endothelin receptor type B
EGR3 early growth response 3
FABP4 fatty acid binding protein 4, adipocyte
FAM65B family with sequence similarity 65, member B
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GPC3 glypican 3
GPX3 glutathione peroxidase 3
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
KLC1 kinesin light chain 1
LPL lipoprotein lipase
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAMLD1 mastermind-like domain containing 1
MRPS2 mitochondrial ribosomal protein S2
MYLK myosin light chain kinase
NMB neuromedin B
NPC2 Niemann-Pick disease, type C2
OXTR oxytocin receptor
PLIN1 perilipin 1
PPIF peptidylprolyl isomerase F
RPL37A ribosomal protein L37a
RPS27L ribosomal protein S27-like
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SORBS1 sorbin and SH3 domain containing 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WBSCR22 Williams Beuren syndrome chromosome region 22