BRD-K20755323_-666_NCIH2073_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K20755323_-666_NCIH2073_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CERS6 ceramide synthase 6
CHKA choline kinase alpha
CPD carboxypeptidase D
CRELD2 cysteine-rich with EGF-like domains 2
DDIT4 DNA-damage-inducible transcript 4
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
FAM129A family with sequence similarity 129, member A
GAL galanin/GMAP prepropeptide
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
NUCB2 nucleobindin 2
PDIA4 protein disulfide isomerase family A, member 4
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
RAB2A RAB2A, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS5 ribosomal protein S5
RRBP1 ribosome binding protein 1
SDC4 syndecan 4
SDF2L1 stromal cell-derived factor 2-like 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPATS2L spermatogenesis associated, serine-rich 2-like
TFF3 trefoil factor 3 (intestinal)
TMED9 transmembrane emp24 protein transport domain containing 9
TXNIP thioredoxin interacting protein
WFDC2 WAP four-disulfide core domain 2
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ATG3 autophagy related 3
AZIN1 antizyme inhibitor 1
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CAST calpastatin
CAV2 caveolin 2
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYCS cytochrome c, somatic
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDNRB endothelin receptor type B
EIF4B eukaryotic translation initiation factor 4B
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KYNU kynureninase
LHFP lipoma HMGIC fusion partner
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MBNL1 muscleblind-like splicing regulator 1
MYH11 myosin, heavy chain 11, smooth muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
ORC1 origin recognition complex, subunit 1
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SERINC5 serine incorporator 5
SFN stratifin
SMAD3 SMAD family member 3
SMS spermine synthase
SNN stannin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
USP22 ubiquitin specific peptidase 22
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WWP1 WW domain containing E3 ubiquitin protein ligase 1