BRD-K20755323_-666_MDST8_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K20755323_-666_MDST8_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM10 ADAM metallopeptidase domain 10
ALCAM activated leukocyte cell adhesion molecule
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASRGL1 asparaginase like 1
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CHEK2 checkpoint kinase 2
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
ECHDC2 enoyl CoA hydratase domain containing 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
GSE1 Gse1 coiled-coil protein
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFI6 interferon, alpha-inducible protein 6
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
JADE3 jade family PHD finger 3
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
LXN latexin
MAGEB2 melanoma antigen family B2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MUC16 mucin 16, cell surface associated
NPEPL1 aminopeptidase-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PSENEN presenilin enhancer gamma secretase subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCARB2 scavenger receptor class B, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC2 stanniocalcin 2
STK10 serine/threonine kinase 10
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TFPI2 tissue factor pathway inhibitor 2
TPD52 tumor protein D52
TRAM1 translocation associated membrane protein 1
UBE2M ubiquitin-conjugating enzyme E2M
UGDH UDP-glucose 6-dehydrogenase
USP3 ubiquitin specific peptidase 3
VCAN versican
XBP1 X-box binding protein 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANOS1 anosmin 1
ASS1 argininosuccinate synthase 1
BMP2 bone morphogenetic protein 2
C3ORF14 chromosome 3 open reading frame 14
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD2 CD2 molecule
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CLTB clathrin, light chain B
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DHCR24 24-dehydrocholesterol reductase
DSG1 desmoglein 1
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FERMT1 fermitin family member 1
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GZMK granzyme K (granzyme 3; tryptase II)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LMNA lamin A/C
LRRN3 leucine rich repeat neuronal 3
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
NSDHL NAD(P) dependent steroid dehydrogenase-like
OGFRL1 opioid growth factor receptor-like 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PKP1 plakophilin 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RBPMS RNA binding protein with multiple splicing
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TYRP1 tyrosinase-related protein 1
VSNL1 visinin-like 1