BRD-K20755323_-666_MCF7_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K20755323_-666_MCF7_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CALR calreticulin
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
JAG1 jagged 1
JUN jun proto-oncogene
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LTF lactotransferrin
LY96 lymphocyte antigen 96
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CTSW cathepsin W
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EMP2 epithelial membrane protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GSTM3 glutathione S-transferase mu 3 (brain)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
KLK11 kallikrein-related peptidase 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MXRA7 matrix-remodelling associated 7
NUP85 nucleoporin 85kDa
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK1 polo-like kinase 1
SQLE squalene epoxidase
TARP TCR gamma alternate reading frame protein
TFRC transferrin receptor