BRD-K20755323_-666_HA1E_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K20755323_-666_HA1E_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ETV5 ets variant 5
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KDM3A lysine (K)-specific demethylase 3A
KRT18 keratin 18, type I
LOC100505650 uncharacterized LOC100505650
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSAP prosaposin
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AURKA aurora kinase A
AURKB aurora kinase B
CCNA2 cyclin A2
CCNF cyclin F
CDA cytidine deaminase
CDC20 cell division cycle 20
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CREB1 cAMP responsive element binding protein 1
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FBLN1 fibulin 1
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
KRT13 keratin 13, type I
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C