BRD-K20755323_-666_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K20755323_-666_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADVL acyl-CoA dehydrogenase, very long chain
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BCL2L2 BCL2-like 2
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHGB chromogranin B
CTSL cathepsin L
CYTIP cytohesin 1 interacting protein
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ETV1 ets variant 1
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPC1 glypican 1
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
IFNGR1 interferon gamma receptor 1
IL10RA interleukin 10 receptor, alpha
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LST1 leukocyte specific transcript 1
LY96 lymphocyte antigen 96
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG2 NDRG family member 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRNP prion protein
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRPA signal-regulatory protein alpha
SLC22A18 solute carrier family 22, member 18
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM176B transmembrane protein 176B
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TST thiosulfate sulfurtransferase (rhodanese)
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA3 annexin A3
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BHLHE40 basic helix-loop-helix family, member e40
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CD47 CD47 molecule
CDA cytidine deaminase
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CENPA centromere protein A
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD1 EH-domain containing 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBP1 guanylate binding protein 1, interferon-inducible
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
KIF20A kinesin family member 20A
KLF6 Kruppel-like factor 6
LAGE3 L antigen family, member 3
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PRSS23 protease, serine, 23
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RPL22 ribosomal protein L22
RPL37A ribosomal protein L37a
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SCEL sciellin
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SQLE squalene epoxidase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
ZMIZ1 zinc finger, MIZ-type containing 1