BRD-K20755323_-666_A673_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K20755323_-666_A673_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE40 basic helix-loop-helix family, member e40
C1S complement component 1, s subcomponent
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CANX calnexin
CCND2 cyclin D2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DSP desmoplakin
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHF ets homologous factor
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL6ST interleukin 6 signal transducer
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LUM lumican
MAGT1 magnesium transporter 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
MFSD10 major facilitator superfamily domain containing 10
MME membrane metallo-endopeptidase
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PERP PERP, TP53 apoptosis effector
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SIK1 salt-inducible kinase 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SQSTM1 sequestosome 1
SRPRB signal recognition particle receptor, B subunit
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TBX3 T-box 3
TMEM41B transmembrane protein 41B
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WFS1 Wolfram syndrome 1 (wolframin)
WIF1 WNT inhibitory factor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCL1 achaete-scute family bHLH transcription factor 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CAPZB capping protein (actin filament) muscle Z-line, beta
CAST calpastatin
CCNE2 cyclin E2
CCNF cyclin F
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FAR2 fatty acyl CoA reductase 2
HES1 hes family bHLH transcription factor 1
HMGN3 high mobility group nucleosomal binding domain 3
INA internexin neuronal intermediate filament protein, alpha
INHBB inhibin, beta B
INSM1 insulinoma-associated 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDN necdin, melanoma antigen (MAGE) family member
NFIB nuclear factor I/B
PBX3 pre-B-cell leukemia homeobox 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRDX2 peroxiredoxin 2
PSRC1 proline/serine-rich coiled-coil 1
PWP1 PWP1 homolog (S. cerevisiae)
RCAN2 regulator of calcineurin 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SOX11 SRY (sex determining region Y)-box 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
XYLT1 xylosyltransferase I