BRD-K20755323_-666_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K20755323_-666_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACOT13 acyl-CoA thioesterase 13
AKR1C2 aldo-keto reductase family 1, member C2
ANG angiogenin, ribonuclease, RNase A family, 5
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CCL5 chemokine (C-C motif) ligand 5
CD38 CD38 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
DDIT3 DNA-damage-inducible transcript 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FTH1 ferritin, heavy polypeptide 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
LPXN leupaxin
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MLPH melanophilin
MME membrane metallo-endopeptidase
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRUNE2 prune homolog 2 (Drosophila)
PYCR1 pyrroline-5-carboxylate reductase 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ANXA3 annexin A3
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CD24 CD24 molecule
CDC42 cell division cycle 42
CENPF centromere protein F, 350/400kDa
CLTB clathrin, light chain B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTSC cathepsin C
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP5 FK506 binding protein 5
FOLR1 folate receptor 1 (adult)
GPATCH8 G patch domain containing 8
H2AFY H2A histone family, member Y
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
KIF20A kinesin family member 20A
LPL lipoprotein lipase
MECOM MDS1 and EVI1 complex locus
NR2F2 nuclear receptor subfamily 2, group F, member 2
PODXL podocalyxin-like
PTMA prothymosin, alpha
QDPR quinoid dihydropteridine reductase
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SEPT7 septin 7
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SRSF2 serine/arginine-rich splicing factor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TPM1 tropomyosin 1 (alpha)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)