BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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33 genes differentially expressed following the BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
CCL2 chemokine (C-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAS1 growth arrest-specific 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MSMO1 methylsterol monooxygenase 1
NFIB nuclear factor I/B
NRN1 neuritin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
UGCG UDP-glucose ceramide glucosyltransferase
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BZW2 basic leucine zipper and W2 domains 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK6 cyclin-dependent kinase 6
FABP6 fatty acid binding protein 6, ileal
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
TKTL1 transketolase-like 1