BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ANPEP alanyl (membrane) aminopeptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CLU clusterin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DRAM1 DNA-damage regulated autophagy modulator 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GDF15 growth differentiation factor 15
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LITAF lipopolysaccharide-induced TNF factor
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
PHGDH phosphoglycerate dehydrogenase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SQLE squalene epoxidase
TRIB3 tribbles pseudokinase 3
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
CADM1 cell adhesion molecule 1
CDCA4 cell division cycle associated 4
COL3A1 collagen, type III, alpha 1
DICER1 dicer 1, ribonuclease type III
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
FOLR1 folate receptor 1 (adult)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KCTD12 potassium channel tetramerization domain containing 12
MARCKS myristoylated alanine-rich protein kinase C substrate
POSTN periostin, osteoblast specific factor
RHOBTB3 Rho-related BTB domain containing 3
RPS5 ribosomal protein S5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)