BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CTGF connective tissue growth factor
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
GAGE3 G antigen 3
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
HOXB6 homeobox B6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MUC16 mucin 16, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NCF2 neutrophil cytosolic factor 2
NFE2 nuclear factor, erythroid 2
NPTX2 neuronal pentraxin II
PEG10 paternally expressed 10
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC12A8 solute carrier family 12, member 8
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
SULF1 sulfatase 1
TF transferrin
THEMIS2 thymocyte selection associated family member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
VCAN versican
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CIT citron rho-interacting serine/threonine kinase
CLTB clathrin, light chain B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FOLR1 folate receptor 1 (adult)
GPX3 glutathione peroxidase 3
GZMK granzyme K (granzyme 3; tryptase II)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLL1 immunoglobulin lambda-like polypeptide 1
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KRT16 keratin 16, type I
MALL mal, T-cell differentiation protein-like
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
NFIB nuclear factor I/B
NPR3 natriuretic peptide receptor 3
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
OPN3 opsin 3
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCZ protein kinase C, zeta
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
REEP5 receptor accessory protein 5
RHCG Rh family, C glycoprotein
RNF167 ring finger protein 167
SCEL sciellin
SELL selectin L
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1