BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K20492338_2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylquinazolin-4-amine KUC108873N_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP2 bone morphogenetic protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EZR ezrin
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GATA2 GATA binding protein 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
MAP7 microtubule-associated protein 7
MED13L mediator complex subunit 13-like
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAP1GAP2 RAP1 GTPase activating protein 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TRIB3 tribbles pseudokinase 3
WDR13 WD repeat domain 13
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANXA1 annexin A1
ARID5B AT rich interactive domain 5B (MRF1-like)
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPF centromere protein F, 350/400kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DUSP22 dual specificity phosphatase 22
GAS1 growth arrest-specific 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
PEG3 paternally expressed 3
PEX11A peroxisomal biogenesis factor 11 alpha
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLPI secretory leukocyte peptidase inhibitor
STOM stomatin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta