BRD-K20401833_N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}thiophene-2-sulfonamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K20401833_N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}thiophene-2-sulfonamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM3 actin binding LIM protein family, member 3
AKAP12 A kinase (PRKA) anchor protein 12
APP amyloid beta (A4) precursor protein
ARL4C ADP-ribosylation factor-like 4C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CRIP2 cysteine-rich protein 2
CRISP3 cysteine-rich secretory protein 3
CST6 cystatin E/M
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
FASN fatty acid synthase
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
GSE1 Gse1 coiled-coil protein
IGFBP6 insulin-like growth factor binding protein 6
IGSF1 immunoglobulin superfamily, member 1
LDOC1 leucine zipper, down-regulated in cancer 1
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
OLFML3 olfactomedin-like 3
PDLIM3 PDZ and LIM domain 3
PDZK1IP1 PDZK1 interacting protein 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLURP1 secreted LY6/PLAUR domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
STC1 stanniocalcin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SULF1 sulfatase 1
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TMPRSS11E transmembrane protease, serine 11E
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TTN titin

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND3 cyclin D3
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CPM carboxypeptidase M
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
DARS aspartyl-tRNA synthetase
DCK deoxycytidine kinase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRAMD3 GRAM domain containing 3
GRB14 growth factor receptor-bound protein 14
HBB hemoglobin, beta
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOPX HOP homeobox
HOXD1 homeobox D1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL6R interleukin 6 receptor
IRS1 insulin receptor substrate 1
ITGB5 integrin, beta 5
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
KLHDC2 kelch domain containing 2
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMS1 LIM and senescent cell antigen-like domains 1
LRRC16A leucine rich repeat containing 16A
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
METTL21B methyltransferase like 21B
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGLL monoglyceride lipase
MITF microphthalmia-associated transcription factor
MOAP1 modulator of apoptosis 1
MRPL19 mitochondrial ribosomal protein L19
MSH6 mutS homolog 6
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG2 NDRG family member 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NKTR natural killer cell triggering receptor
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
OSBPL9 oxysterol binding protein-like 9
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFC platelet derived growth factor C
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40B RAB40B, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS13 regulator of G-protein signaling 13
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SF1 splicing factor 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SKP1 S-phase kinase-associated protein 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC35E3 solute carrier family 35, member E3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMS spermine synthase
SNAP23 synaptosomal-associated protein, 23kDa
SOAT1 sterol O-acyltransferase 1
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM2D3 TM2 domain containing 3
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1
USP1 ubiquitin specific peptidase 1
VAMP8 vesicle-associated membrane protein 8