BRD-K20285085_fostamatinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K20285085_fostamatinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
ASPN asporin
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
CEP57 centrosomal protein 57kDa
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
FOXO4 forkhead box O4
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
HIST1H2BD histone cluster 1, H2bd
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
ITM2C integral membrane protein 2C
KIAA1033 KIAA1033
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MAP2K5 mitogen-activated protein kinase kinase 5
MTSS1 metastasis suppressor 1
MX2 MX dynamin-like GTPase 2
MYO6 myosin VI
NBPF10 neuroblastoma breakpoint family, member 10
NDN necdin, melanoma antigen (MAGE) family member
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RDX radixin
S100A8 S100 calcium binding protein A8
SCD5 stearoyl-CoA desaturase 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SRPK2 SRSF protein kinase 2
SSR4 signal sequence receptor, delta
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TPR translocated promoter region, nuclear basket protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ARL4C ADP-ribosylation factor-like 4C
ATF5 activating transcription factor 5
BID BH3 interacting domain death agonist
CALML5 calmodulin-like 5
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF5A eukaryotic translation initiation factor 5A
ETNK1 ethanolamine kinase 1
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
GTPBP8 GTP-binding protein 8 (putative)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PFKP phosphofructokinase, platelet
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
PSCA prostate stem cell antigen
RFC2 replication factor C (activator 1) 2, 40kDa
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
STK39 serine threonine kinase 39
TFRC transferrin receptor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC6 zinc finger, DHHC-type containing 6