BRD-K20285085_fostamatinib_HME1_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K20285085_fostamatinib_HME1_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C7 complement component 7
CADPS2 Ca++-dependent secretion activator 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CRYAB crystallin, alpha B
DOK5 docking protein 5
DSP desmoplakin
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EGR2 early growth response 2
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
HOXA5 homeobox A5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KRT19 keratin 19, type I
LDB2 LIM domain binding 2
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NEBL nebulette
NES nestin
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG3 paternally expressed 3
PER1 period circadian clock 1
PLSCR4 phospholipid scramblase 4
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAP30 Sin3A-associated protein, 30kDa
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TMPRSS3 transmembrane protease, serine 3
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AXIN1 axin 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK6 cyclin-dependent kinase 6
CLGN calmegin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPX1 glutathione peroxidase 1
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
KLHL9 kelch-like family member 9
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCDH7 protocadherin 7
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PLS1 plastin 1
PRKCA protein kinase C, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLPI secretory leukocyte peptidase inhibitor
SPRR3 small proline-rich protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TMPRSS2 transmembrane protease, serine 2
UGCG UDP-glucose ceramide glucosyltransferase
WNT5A wingless-type MMTV integration site family, member 5A
ZC3H12A zinc finger CCCH-type containing 12A