BRD-K20285085_fostamatinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K20285085_fostamatinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
BAMBI BMP and activin membrane-bound inhibitor
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CRABP1 cellular retinoic acid binding protein 1
CSNK1D casein kinase 1, delta
CTSK cathepsin K
ECH1 enoyl CoA hydratase 1, peroxisomal
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MAOA monoamine oxidase A
MATN2 matrilin 2
MFAP2 microfibrillar-associated protein 2
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PRKX protein kinase, X-linked
RTN2 reticulon 2
SFRP4 secreted frizzled-related protein 4
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SQRDL sulfide quinone reductase-like (yeast)
STON1 stonin 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TKT transketolase
TPD52L1 tumor protein D52-like 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
AK4 adenylate kinase 4
BDNF brain-derived neurotrophic factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL9A3 collagen, type IX, alpha 3
DOCK10 dedicator of cytokinesis 10
DUSP10 dual specificity phosphatase 10
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GOLT1B golgi transport 1B
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSTO1 glutathione S-transferase omega 1
HMGA2 high mobility group AT-hook 2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LDLR low density lipoprotein receptor
MINA MYC induced nuclear antigen
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
SACS sacsin molecular chaperone
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPAG4 sperm associated antigen 4
SSR1 signal sequence receptor, alpha
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
TFRC transferrin receptor
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFC vascular endothelial growth factor C