BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K20168484_1h-indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)- [cas]_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC3B C-type lectin domain family 3, member B
COMP cartilage oligomeric matrix protein
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
GARS glycyl-tRNA synthetase
HAPLN1 hyaluronan and proteoglycan link protein 1
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
INHBE inhibin, beta E
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1D myosin ID
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SST somatostatin
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DMD dystrophin
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
LDHB lactate dehydrogenase B
LTF lactotransferrin
PLK2 polo-like kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A