BRD-K19687926_lapatinib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K19687926_lapatinib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
AUTS2 autism susceptibility candidate 2
CAPN1 calpain 1, (mu/I) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CLDN10 claudin 10
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
JUP junction plakoglobin
KAT6B K(lysine) acetyltransferase 6B
KIAA1324 KIAA1324
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LEFTY1 left-right determination factor 1
MAP7 microtubule-associated protein 7
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NEBL nebulette
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLXNB2 plexin B2
PROM1 prominin 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC35E3 solute carrier family 35, member E3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMPRSS3 transmembrane protease, serine 3
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FGL2 fibrinogen-like 2
FKBP11 FK506 binding protein 11, 19 kDa
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
LMNB2 lamin B2
LMO3 LIM domain only 3 (rhombotin-like 2)
MALL mal, T-cell differentiation protein-like
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDN necdin, melanoma antigen (MAGE) family member
NOP16 NOP16 nucleolar protein
NTS neurotensin
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCDH9 protocadherin 9
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC4 structural maintenance of chromosomes 4
SPARCL1 SPARC-like 1 (hevin)
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
TMEM97 transmembrane protein 97
TRIB2 tribbles pseudokinase 2
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S