BRD-K19687926_lapatinib_SKBR3_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K19687926_lapatinib_SKBR3_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN10 claudin 10
CLU clusterin
COMT catechol-O-methyltransferase
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
DEPTOR DEP domain containing MTOR-interacting protein
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HP haptoglobin
KAT6B K(lysine) acetyltransferase 6B
KLHDC10 kelch domain containing 10
KLHDC2 kelch domain containing 2
LCN2 lipocalin 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
MLPH melanophilin
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
MVP major vault protein
NMRK1 nicotinamide riboside kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
OXTR oxytocin receptor
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PRSS8 protease, serine, 8
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNAP23 synaptosomal-associated protein, 23kDa
SPDEF SAM pointed domain containing ETS transcription factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F2 E2F transcription factor 2
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
IGKC immunoglobulin kappa constant
IGLV3-19 immunoglobulin lambda variable 3-19
IRF8 interferon regulatory factor 8
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
THBS2 thrombospondin 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein