BRD-K19540840_saracatinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K19540840_saracatinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX6 armadillo repeat containing, X-linked 6
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ASS1 argininosuccinate synthase 1
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
CA11 carbonic anhydrase XI
CAB39 calcium binding protein 39
CAPN1 calpain 1, (mu/I) large subunit
CAT catalase
CCNG1 cyclin G1
CCNG2 cyclin G2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COL15A1 collagen, type XV, alpha 1
COL21A1 collagen, type XXI, alpha 1
CPE carboxypeptidase E
CTSC cathepsin C
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL13 chemokine (C-X-C motif) ligand 13
DPT dermatopontin
DUSP22 dual specificity phosphatase 22
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134A family with sequence similarity 134, member A
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H2AC histone cluster 1, H2ac
HLF hepatic leukemia factor
HMGN3 high mobility group nucleosomal binding domain 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KIAA0125 KIAA0125
L1CAM L1 cell adhesion molecule
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LMBRD1 LMBR1 domain containing 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LSP1 lymphocyte-specific protein 1
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
METTL7A methyltransferase like 7A
MVP major vault protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEU1 sialidase 1 (lysosomal sialidase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
OBSL1 obscurin-like 1
OLFM1 olfactomedin 1
OLFML2A olfactomedin-like 2A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL31 ribosomal protein L31
S100A4 S100 calcium binding protein A4
SDCBP syndecan binding protein (syntenin)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM135 transmembrane protein 135
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
WISP2 WNT1 inducible signaling pathway protein 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BGN biglycan
BMP2 bone morphogenetic protein 2
C3ORF52 chromosome 3 open reading frame 52
CCND1 cyclin D1
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP55 centrosomal protein 55kDa
COL5A2 collagen, type V, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DCK deoxycytidine kinase
DENND2D DENN/MADD domain containing 2D
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLX2 distal-less homeobox 2
DSP desmoplakin
ECT2 epithelial cell transforming 2
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FGF2 fibroblast growth factor 2 (basic)
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL11 interleukin 11
IL13RA2 interleukin 13 receptor, alpha 2
IL7R interleukin 7 receptor
INHBA inhibin, beta A
KIAA0226L KIAA0226-like
KLK10 kallikrein-related peptidase 10
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LMCD1 LIM and cysteine-rich domains 1
MALL mal, T-cell differentiation protein-like
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
NEK7 NIMA-related kinase 7
NID1 nidogen 1
NKX3-1 NK3 homeobox 1
NRG1 neuregulin 1
NUP160 nucleoporin 160kDa
NUPL1 nucleoporin like 1
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNH1 ribonuclease/angiogenin inhibitor 1
S100A12 S100 calcium binding protein A12
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SRGN serglycin
STK17A serine/threonine kinase 17a
SULF1 sulfatase 1
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A
WWC2 WW and C2 domain containing 2