BRD-K19540840_saracatinib_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

107 genes differentially expressed following the BRD-K19540840_saracatinib_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CASP3 caspase 3, apoptosis-related cysteine peptidase
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
HP haptoglobin
KIAA0226L KIAA0226-like
KRT15 keratin 15, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MUC16 mucin 16, cell surface associated
NSG1 neuron specific gene family member 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG3 paternally expressed 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBMS1 RNA binding motif, single stranded interacting protein 1
RIMS3 regulating synaptic membrane exocytosis 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SSBP2 single-stranded DNA binding protein 2
STAP2 signal transducing adaptor family member 2
STOM stomatin
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
UBA7 ubiquitin-like modifier activating enzyme 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD86 CD86 molecule
CDC45 cell division cycle 45
COG7 component of oligomeric golgi complex 7
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GDF15 growth differentiation factor 15
GOLM1 golgi membrane protein 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMG20B high mobility group 20B
HMGA1 high mobility group AT-hook 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITGB5 integrin, beta 5
KLF10 Kruppel-like factor 10
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCM3 minichromosome maintenance complex component 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
P3H2 prolyl 3-hydroxylase 2
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PTRF polymerase I and transcript release factor
PXDN peroxidasin
RFC2 replication factor C (activator 1) 2, 40kDa
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S