BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

29 genes differentially expressed following the BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NFE2L2 nuclear factor, erythroid 2-like 2
PSPH phosphoserine phosphatase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
STAR steroidogenic acute regulatory protein
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
MYBPC1 myosin binding protein C, slow type
NRIP1 nuclear receptor interacting protein 1
RGS1 regulator of G-protein signaling 1
SNX7 sorting nexin 7
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WWTR1 WW domain containing transcription regulator 1
ZIC1 Zic family member 1