BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

44 genes differentially expressed following the BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
AXIN1 axin 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
FADS1 fatty acid desaturase 1
FBN2 fibrillin 2
FERMT2 fermitin family member 2
G0S2 G0/G1 switch 2
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
ISG20 interferon stimulated exonuclease gene 20kDa
KRT14 keratin 14, type I
MAP1B microtubule-associated protein 1B
NDRG1 N-myc downstream regulated 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
STC1 stanniocalcin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
CDC25A cell division cycle 25A
COL3A1 collagen, type III, alpha 1
CPVL carboxypeptidase, vitellogenic-like
EDNRB endothelin receptor type B
HOXC6 homeobox C6
PDLIM5 PDZ and LIM domain 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)