BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL2A1 BCL2-related protein A1
CAV2 caveolin 2
CHN2 chimerin 2
CPVL carboxypeptidase, vitellogenic-like
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DUSP2 dual specificity phosphatase 2
EMP1 epithelial membrane protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
HIP1R huntingtin interacting protein 1 related
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IVNS1ABP influenza virus NS1A binding protein
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LRP4 low density lipoprotein receptor-related protein 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NUPL1 nucleoporin like 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
RGS1 regulator of G-protein signaling 1
SC5D sterol-C5-desaturase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYNGR3 synaptogyrin 3
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASS1 argininosuccinate synthase 1
C1R complement component 1, r subcomponent
CCND2 cyclin D2
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRDL1 chordin-like 1
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ERBB4 erb-b2 receptor tyrosine kinase 4
FNBP1 formin binding protein 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAN1A1 mannosidase, alpha, class 1A, member 1
MKKS McKusick-Kaufman syndrome
MMD monocyte to macrophage differentiation-associated
NMT1 N-myristoyltransferase 1
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFPI2 tissue factor pathway inhibitor 2
TMEM5 transmembrane protein 5
TNS3 tensin 3
TOX3 TOX high mobility group box family member 3