BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

40 genes differentially expressed following the BRD-K19410523_6-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
EMP1 epithelial membrane protein 1
ESRP1 epithelial splicing regulatory protein 1
FN1 fibronectin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRIA2 glutamate receptor, ionotropic, AMPA 2
HEPH hephaestin
HIP1R huntingtin interacting protein 1 related
ITGA6 integrin, alpha 6
JAG1 jagged 1
LPIN1 lipin 1
MALL mal, T-cell differentiation protein-like
PDZK1IP1 PDZK1 interacting protein 1
PMP22 peripheral myelin protein 22
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPSAB1 tryptase alpha/beta 1

decreased expression

Symbol Name
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
ELOVL2 ELOVL fatty acid elongase 2
HIST1H4C histone cluster 1, H4c
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SNX7 sorting nexin 7
TFPI2 tissue factor pathway inhibitor 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZNF331 zinc finger protein 331