BRD-K19295594_-666_HEPG2_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K19295594_-666_HEPG2_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
COG5 component of oligomeric golgi complex 5
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FLNB filamin B, beta
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM4B lysine (K)-specific demethylase 4B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
STK39 serine threonine kinase 39
TF transferrin
TGFBR3 transforming growth factor, beta receptor III
TRIB1 tribbles pseudokinase 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
YARS tyrosyl-tRNA synthetase
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
CCNG1 cyclin G1
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
DCN decorin
FGFR2 fibroblast growth factor receptor 2
GAL galanin/GMAP prepropeptide
H2AFX H2A histone family, member X
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KIAA0907 KIAA0907
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
MCAM melanoma cell adhesion molecule
MDH1 malate dehydrogenase 1, NAD (soluble)
METTL3 methyltransferase like 3
MMP9 matrix metallopeptidase 9
MUC16 mucin 16, cell surface associated
OXA1L oxidase (cytochrome c) assembly 1-like
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SELL selectin L
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TFRC transferrin receptor