BRD-K19220233_JNK-9L_SKBR3_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K19220233_JNK-9L_SKBR3_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOB aldolase B, fructose-bisphosphate
APLP1 amyloid beta (A4) precursor-like protein 1
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BLNK B-cell linker
CADPS2 Ca++-dependent secretion activator 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNE2 cyclin E2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L2 chitinase 3-like 2
CIT citron rho-interacting serine/threonine kinase
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
EIF5A eukaryotic translation initiation factor 5A
FGF13 fibroblast growth factor 13
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GLI2 GLI family zinc finger 2
GPX1 glutathione peroxidase 1
INA internexin neuronal intermediate filament protein, alpha
KIAA0226L KIAA0226-like
KLHL21 kelch-like family member 21
LGMN legumain
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP3 latent transforming growth factor beta binding protein 3
MAB21L2 mab-21-like 2 (C. elegans)
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MAST4 microtubule associated serine/threonine kinase family member 4
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSN moesin
MYO1B myosin IB
MYO6 myosin VI
NDN necdin, melanoma antigen (MAGE) family member
NTS neurotensin
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDLIM4 PDZ and LIM domain 4
PENK proenkephalin
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SMAD2 SMAD family member 2
SNAP25 synaptosomal-associated protein, 25kDa
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYNM synemin, intermediate filament protein
TGFBI transforming growth factor, beta-induced, 68kDa
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN4 tetraspanin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WDTC1 WD and tetratricopeptide repeats 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARF6 ADP-ribosylation factor 6
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN4 claudin 4
CLU clusterin
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F2RL1 coagulation factor II (thrombin) receptor-like 1
GATA2 GATA binding protein 2
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIC2 hypermethylated in cancer 2
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL32 interleukin 32
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT23 keratin 23, type I
MAT2A methionine adenosyltransferase II, alpha
MSMO1 methylsterol monooxygenase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NOTCH2 notch 2
NOV nephroblastoma overexpressed
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROS1 protein S (alpha)
PRPF4 pre-mRNA processing factor 4
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB14 RAB14, member RAS oncogene family
RBM15 RNA binding motif protein 15
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
U2AF1 U2 small nuclear RNA auxiliary factor 1
WT1 Wilms tumor 1