BRD-K19220233_JNK-9L_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K19220233_JNK-9L_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMPD3 adenosine monophosphate deaminase 3
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOA2 apolipoprotein A-II
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD163 CD163 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP70 centrosomal protein 70kDa
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DSP desmoplakin
DST dystonin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ERBB4 erb-b2 receptor tyrosine kinase 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM8A1 family with sequence similarity 8, member A1
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL2RG interleukin 2 receptor, gamma
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGMN legumain
LMO3 LIM domain only 3 (rhombotin-like 2)
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NKTR natural killer cell triggering receptor
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSENEN presenilin enhancer gamma secretase subunit
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SPARCL1 SPARC-like 1 (hevin)
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BICC1 BicC family RNA binding protein 1
CALML3 calmodulin-like 3
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGFR2 fibroblast growth factor receptor 2
GYG1 glycogenin 1
HEATR1 HEAT repeat containing 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ILF2 interleukin enhancer binding factor 2
INHBB inhibin, beta B
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MED24 mediator complex subunit 24
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM38 RNA binding motif protein 38
RIN2 Ras and Rab interactor 2
RNF19B ring finger protein 19B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SMC4 structural maintenance of chromosomes 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST7 suppression of tumorigenicity 7
STIP1 stress-induced phosphoprotein 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIL TLR4 interactor with leucine-rich repeats
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBAP2L ubiquitin associated protein 2-like
UBE3C ubiquitin protein ligase E3C
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZWINT ZW10 interacting kinetochore protein