BRD-K19220233_JNK-9L_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-K19220233_JNK-9L_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AIF1 allograft inflammatory factor 1
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMBP alpha-1-microglobulin/bikunin precursor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ANXA9 annexin A9
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BHMT2 betaine--homocysteine S-methyltransferase 2
BIRC3 baculoviral IAP repeat containing 3
BSG basigin (Ok blood group)
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CALB1 calbindin 1, 28kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CD38 CD38 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD93 CD93 molecule
CD96 CD96 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFI complement factor I
CHERP calcium homeostasis endoplasmic reticulum protein
CLIC5 chloride intracellular channel 5
CLU clusterin
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DIO1 deiodinase, iodothyronine, type I
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FBXO2 F-box protein 2
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
FRS2 fibroblast growth factor receptor substrate 2
FUCA1 fucosidase, alpha-L- 1, tissue
GAS2 growth arrest-specific 2
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GOLGA8H golgin A8 family, member H
GPR171 G protein-coupled receptor 171
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLF hepatic leukemia factor
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITM2A integral membrane protein 2A
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
KYNU kynureninase
LAGE3 L antigen family, member 3
LAMP1 lysosomal-associated membrane protein 1
LRRC17 leucine rich repeat containing 17
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCTP1 multiple C2 domains, transmembrane 1
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MICB MHC class I polypeptide-related sequence B
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NCF1C neutrophil cytosolic factor 1C pseudogene
NME5 NME/NM23 family member 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM1 olfactomedin 1
OPTN optineurin
ORAI2 ORAI calcium release-activated calcium modulator 2
ORM1 orosomucoid 1
PCBP2 poly(rC) binding protein 2
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PFN2 profilin 2
PLD3 phospholipase D family, member 3
PLVAP plasmalemma vesicle associated protein
PNMA1 paraneoplastic Ma antigen 1
PRDX4 peroxiredoxin 4
PSENEN presenilin enhancer gamma secretase subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS5 ribosomal protein S5
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RUNX3 runt-related transcription factor 3
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TRBC1 T cell receptor beta constant 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TWIST1 twist family bHLH transcription factor 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRH ubiquinol-cytochrome c reductase hinge protein
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WT1 Wilms tumor 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AXIN1 axin 1
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP7 charged multivesicular body protein 7
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL13A1 collagen, type XIII, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CREB1 cAMP responsive element binding protein 1
CTBP2 C-terminal binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DES desmin
DKK1 dickkopf WNT signaling pathway inhibitor 1
EAPP E2F-associated phosphoprotein
ECD ecdysoneless homolog (Drosophila)
EED embryonic ectoderm development
EFS embryonal Fyn-associated substrate
EIF1 eukaryotic translation initiation factor 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ETV1 ets variant 1
EXT1 exostosin glycosyltransferase 1
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FANCL Fanconi anemia, complementation group L
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTA4 glutathione S-transferase alpha 4
HMGB1 high mobility group box 1
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOPX HOP homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
INPP1 inositol polyphosphate-1-phosphatase
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
KRT15 keratin 15, type I
LBR lamin B receptor
LIMCH1 LIM and calponin homology domains 1
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NUP85 nucleoporin 85kDa
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PDS5A PDS5 cohesin associated factor A
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PWP1 PWP1 homolog (S. cerevisiae)
RAB4A RAB4A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
S100A10 S100 calcium binding protein A10
SESN1 sestrin 1
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLN sarcolipin
SOX4 SRY (sex determining region Y)-box 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBL1X transducin (beta)-like 1X-linked
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TP63 tumor protein p63
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB4B tubulin, beta 4B class IVb
YBX3 Y box binding protein 3
ZBED5 zinc finger, BED-type containing 5
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF638 zinc finger protein 638