BRD-K19220233_JNK-9L_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

259 genes differentially expressed following the BRD-K19220233_JNK-9L_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ACKR3 atypical chemokine receptor 3
ADCY1 adenylate cyclase 1 (brain)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARL3 ADP-ribosylation factor-like 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CAPN1 calpain 1, (mu/I) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CECR1 cat eye syndrome chromosome region, candidate 1
CFI complement factor I
CHMP4A charged multivesicular body protein 4A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC5 chloride intracellular channel 5
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSO cathepsin O
CTSS cathepsin S
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCTD dCMP deaminase
DDHD2 DDHD domain containing 2
DSE dermatan sulfate epimerase
DSG2 desmoglein 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENOSF1 enolase superfamily member 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
FAM134B family with sequence similarity 134, member B
FECH ferrochelatase
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
GUK1 guanylate kinase 1
HBE1 hemoglobin, epsilon 1
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
OLFM4 olfactomedin 4
ORAI2 ORAI calcium release-activated calcium modulator 2
ORM1 orosomucoid 1
PCOLCE procollagen C-endopeptidase enhancer
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLD3 phospholipase D family, member 3
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM47 transmembrane protein 47
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPGS2 tubulin polyglutamylase complex subunit 2
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VWF von Willebrand factor
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AXIN1 axin 1
B3GNT1
BCL6 B-cell CLL/lymphoma 6
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITPKB inositol-trisphosphate 3-kinase B
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LBR lamin B receptor
LDLR low density lipoprotein receptor
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
METTL3 methyltransferase like 3
MSMO1 methylsterol monooxygenase 1
MTERF3 mitochondrial transcription termination factor 3
MYBPC1 myosin binding protein C, slow type
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PUF60 poly-U binding splicing factor 60KDa
PYGB phosphorylase, glycogen; brain
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC38A2 solute carrier family 38, member 2
SOX9 SRY (sex determining region Y)-box 9
SPRR1B small proline-rich protein 1B
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOB1 transducer of ERBB2, 1
TRAPPC3 trafficking protein particle complex 3
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UMPS uridine monophosphate synthetase
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF185 zinc finger protein 185 (LIM domain)