BRD-K19220233_JNK-9L_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K19220233_JNK-9L_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ASPN asporin
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CXCL6 chemokine (C-X-C motif) ligand 6
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
GPX3 glutathione peroxidase 3
GSAP gamma-secretase activating protein
HAPLN1 hyaluronan and proteoglycan link protein 1
HIP1 huntingtin interacting protein 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
KIAA0226L KIAA0226-like
LAPTM4B lysosomal protein transmembrane 4 beta
LPL lipoprotein lipase
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP7 matrix metallopeptidase 7
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PIPOX pipecolic acid oxidase
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TXNL4A thioredoxin-like 4A

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATXN7 ataxin 7
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BCOR BCL6 corepressor
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2AIP CDKN2A interacting protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLP1 cleavage and polyadenylation factor I subunit 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRABP1 cellular retinoic acid binding protein 1
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGR2 early growth response 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADD Fas (TNFRSF6)-associated via death domain
FAM208B family with sequence similarity 208, member B
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FBXL12 F-box and leucine-rich repeat protein 12
FBXO34 F-box protein 34
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FOXF2 forkhead box F2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
KRT14 keratin 14, type I
LTF lactotransferrin
MAD2L1BP MAD2L1 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUPL1 nucleoporin like 1
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDM2 PR domain containing 2, with ZNF domain
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF113A ring finger protein 113A
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SHOX2 short stature homeobox 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A46 solute carrier family 25, member 46
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD1 SMAD family member 1
SMAD7 SMAD family member 7
SNRK SNF related kinase
SOCS1 suppressor of cytokine signaling 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
VCPKMT valosin containing protein lysine (K) methyltransferase
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
WLS wntless Wnt ligand secretion mediator
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF107 zinc finger protein 107
ZNF12 zinc finger protein 12
ZNF267 zinc finger protein 267