BRD-K19220233_JNK-9L_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K19220233_JNK-9L_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AREG amphiregulin
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
CD302 CD302 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CHMP4A charged multivesicular body protein 4A
CLDN18 claudin 18
COL1A2 collagen, type I, alpha 2
COMMD8 COMM domain containing 8
CPVL carboxypeptidase, vitellogenic-like
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GPM6A glycoprotein M6A
HIP1 huntingtin interacting protein 1
HOPX HOP homeobox
IL13RA2 interleukin 13 receptor, alpha 2
ITFG1 integrin alpha FG-GAP repeat containing 1
KDM5D lysine (K)-specific demethylase 5D
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
PADI2 peptidyl arginine deiminase, type II
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAC8 placenta-specific 8
PODXL podocalyxin-like
POPDC3 popeye domain containing 3
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNNC1 troponin C type 1 (slow)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
AHR aryl hydrocarbon receptor
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATXN7 ataxin 7
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCNF cyclin F
CD24 CD24 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLP1 cleavage and polyadenylation factor I subunit 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EFNB2 ephrin-B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FEM1B fem-1 homolog b (C. elegans)
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GMNN geminin, DNA replication inhibitor
GREM1 gremlin 1, DAN family BMP antagonist
GTF2B general transcription factor IIB
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIN Kin17 DNA and RNA binding protein
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAD2L1BP MAD2L1 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MED21 mediator complex subunit 21
MEIS2 Meis homeobox 2
MID1IP1 MID1 interacting protein 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT1 nuclear transport factor 2-like export factor 1
OSR2 odd-skipped related transciption factor 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCP4 Purkinje cell protein 4
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDM2 PR domain containing 2, with ZNF domain
PTPRO protein tyrosine phosphatase, receptor type, O
PTRH2 peptidyl-tRNA hydrolase 2
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSBN1 round spermatid basic protein 1
SAP30 Sin3A-associated protein, 30kDa
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAI2 snail family zinc finger 2
SNRK SNF related kinase
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
STK26 serine/threonine protein kinase 26
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNC tenascin C
TOB2 transducer of ERBB2, 2
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF12 zinc finger protein 12
ZNF267 zinc finger protein 267
ZNF281 zinc finger protein 281
ZNF394 zinc finger protein 394