BRD-K19220233_JNK-9L_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K19220233_JNK-9L_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
AIF1 allograft inflammatory factor 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
BACE2 beta-site APP-cleaving enzyme 2
C1QA complement component 1, q subcomponent, A chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD52 CD52 molecule
CD84 CD84 molecule
CFD complement factor D (adipsin)
CLU clusterin
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSTN destrin (actin depolymerizing factor)
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LRRC17 leucine rich repeat containing 17
LTBP3 latent transforming growth factor beta binding protein 3
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MN1 meningioma (disrupted in balanced translocation) 1
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB1 nucleobindin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PCBP2 poly(rC) binding protein 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF1 splicing factor 1
SFTPC surfactant protein C
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
SPEN spen family transcriptional repressor
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TP53TG1 TP53 target 1 (non-protein coding)
TPP1 tripeptidyl peptidase I
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TYROBP TYRO protein tyrosine kinase binding protein
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
VWA5A von Willebrand factor A domain containing 5A
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ASXL2 additional sex combs like transcriptional regulator 2
ATP10D ATPase, class V, type 10D
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLMH bleomycin hydrolase
BMP4 bone morphogenetic protein 4
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CST1 cystatin SN
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EED embryonic ectoderm development
EIF4E eukaryotic translation initiation factor 4E
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FEN1 flap structure-specific endonuclease 1
HMGB3 high mobility group box 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
LASP1 LIM and SH3 protein 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MYO10 myosin X
PCNA proliferating cell nuclear antigen
PDS5A PDS5 cohesin associated factor A
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP4 retinoblastoma binding protein 4
RGS4 regulator of G-protein signaling 4
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
SIX2 SIX homeobox 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TRAM2 translocation associated membrane protein 2
TXLNA taxilin alpha
USP1 ubiquitin specific peptidase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XPO1 exportin 1
XPO7 exportin 7
ZNF638 zinc finger protein 638