BRD-K19220233_JNK-9L_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AGTR1 angiotensin II receptor, type 1
APOE apolipoprotein E
BAD BCL2-associated agonist of cell death
C6ORF62 chromosome 6 open reading frame 62
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CNN3 calponin 3, acidic
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FASN fatty acid synthase
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
HAPLN1 hyaluronan and proteoglycan link protein 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IGFBP7 insulin-like growth factor binding protein 7
LEPR leptin receptor
LPL lipoprotein lipase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NRGN neurogranin (protein kinase C substrate, RC3)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHKB phosphorylase kinase, beta
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOD2 superoxide dismutase 2, mitochondrial
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS1 thrombospondin 1
TPGS2 tubulin polyglutamylase complex subunit 2
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
VCAN versican

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ARID4B AT rich interactive domain 4B (RBP1-like)
B3GNT1
C1ORF106 chromosome 1 open reading frame 106
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
FZD7 frizzled class receptor 7
IER2 immediate early response 2
IGL immunoglobulin lambda locus
KLF11 Kruppel-like factor 11
MGP matrix Gla protein
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
PLAC8 placenta-specific 8
PURA purine-rich element binding protein A
RPP38 ribonuclease P/MRP 38kDa subunit
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SESN1 sestrin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SYNM synemin, intermediate filament protein
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
USP1 ubiquitin specific peptidase 1