BRD-K19220233_JNK-9L_MCF7_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF7_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
CLGN calmegin
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
FABP1 fatty acid binding protein 1, liver
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
MXRA8 matrix-remodelling associated 8
NELL2 NEL-like 2 (chicken)
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PENK proenkephalin
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PRR7 proline rich 7 (synaptic)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS4 thrombospondin 4
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
C1ORF106 chromosome 1 open reading frame 106
CCNE2 cyclin E2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GNAS GNAS complex locus
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXB6 homeobox B6
HOXB7 homeobox B7
KAT6B K(lysine) acetyltransferase 6B
KLHL9 kelch-like family member 9
LPAR6 lysophosphatidic acid receptor 6
MAN2A1 mannosidase, alpha, class 2A, member 1
NET1 neuroepithelial cell transforming 1
NPTX1 neuronal pentraxin I
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE4 transducin-like enhancer of split 4
TNS3 tensin 3
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586